Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis | Zendy

Gaelle Makafe | Zendy; Yuanyuan Cao | Zendy; Yaoju Tan | Zendy; Mugweru Julius | Zendy; Xiaogang Li | Zendy; Changwei Wang | Zendy; Moses Njire | Zendy; Xingshan Cai | Zendy; Tianzhou Liu | Zendy; Bangxing Wang | Zendy; Wei Pang | Zendy; Shouyong Tan | Zendy; Buchang Zhang | Zendy; Wing Wai Yew | Zendy; Gyanu Lamichhane | Zendy; Jintao Guo | Zendy; Tianyu Zhang | Zendy

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Role of the Cys154Arg Substitution in Ribosomal Protein L3 in Oxazolidinone Resistance in Mycobacterium tuberculosis

Author(s) -

Gaelle Makafe,

Yuanyuan Cao,

Yaoju Tan,

Mugweru Julius,

Xiaogang Li,

Changwei Wang,

Moses Njire,

Xingshan Cai,

Tianzhou Liu,

Bangxing Wang,

Wei Pang,

Shouyong Tan,

Buchang Zhang,

Wing Wai Yew,

Gyanu Lamichhane,

Jintao Guo,

Tianyu Zhang

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00152-16

Subject(s) - mycobacterium tuberculosis , microbiology and biotechnology , recombinant dna , mycobacterium , biology , gene , ribosomal rna , mutation , ribosomal protein , tuberculosis , genetics , chemistry , bacteria , ribosome , rna , medicine , pathology

We expressed the wild-typerplC and mutatedrplC (Cys154Arg) genes, respectively, inMycobacterium tuberculosis H37Ra and H37Rv in an attempt to delineate the role ofrplC (Cys154Arg) regarding oxazolidinone resistance. An increase of the MICs of linezolid (LZD) and sutezolid (PNU-100480, PNU) against the recombinant mycobacteria with overexpressedrplC mutation (Cys154Arg) was found, suggesting therplC gene is a determinant of bacillary susceptibilities to LZD and PNU.

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