Open AccessIn Vivo Therapeutic Effect of Gatifloxacin on BALB/c Mice Infected with Nocardia brasiliensis
Author(s) -
Alejandra Daw-Garza,
Oliverio Welsh,
Salvador SaidFernández,
Héctor Gerardo Lozano-Garza,
Noemí Waksman,
Norma Cavazos-Rocha,
Jorge OcampoCandiani,
Lucio Vera-Cabrera
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00148-08
Subject(s) - gatifloxacin , linezolid , balb/c , in vivo , nocardia brasiliensis , microbiology and biotechnology , nocardia , pharmacology , medicine , biology , antibiotics , immunology , bacteria , nocardiosis , staphylococcus aureus , levofloxacin , genetics , immune system , vancomycin
In the present work, we evaluated the effect of gatifloxacin on the evolution of experimental murine infection withNocardia brasiliensis using linezolid as a control. Gatifloxacin was injected subcutaneously at 100 mg/kg body weight every 8 h for 4 weeks. This compound was equally as efficient as linezolid in reducing the production of lesions.