Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis | Zendy

Sangun Lee | Zendy; Melanie Ginese | Zendy; Gillian Beamer | Zendy; Hillary Danz | Zendy; Donald Girouard | Zendy; Susan Chapman-Bonofiglio | Zendy; Minhee Lee | Zendy; Matthew A. Hulverson | Zendy; Ryan Choi | Zendy; Grant R. Whitman | Zendy; Kayode K. Ojo | Zendy; Samuel L.M. Arnold | Zendy; Wesley C. Van Voorhis | Zendy; Saul Tzipori | Zendy

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Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis

Author(s) -

Sangun Lee,

Melanie Ginese,

Gillian Beamer,

Hillary Danz,

Donald Girouard,

Susan Chapman-Bonofiglio,

Minhee Lee,

Matthew A. Hulverson,

Ryan Choi,

Grant R. Whitman,

Kayode K. Ojo,

Samuel L.M. Arnold,

Wesley C. Van Voorhis,

Saul Tzipori

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00147-18

Subject(s) - cryptosporidium , diarrhea , cryptosporidium parvum , microbiology and biotechnology , acute diarrhea , biology , medicine , immunology , virology , gastroenterology , feces

Recent reports highlighting the global significance of cryptosporidiosis among children have renewed efforts to develop control measures. We evaluated the efficacy of bumped kinase inhibitor (BKI) 1369 in the gnotobiotic piglet model of acute diarrhea caused byCryptosporidium hominis , the species responsible for most human cases. Five-day treatment with BKI 1369 reduced signs of disease early during treatment compared to those of untreated animals. Piglets treated with BKI 1369 exhibited significant reductions of oocyst excretion, mucosal colonization byC. hominis , and mucosal lesions, which resulted in considerable symptomatic improvement. BKI 1369 reduced the parasite burden and disease severity in the gnotobiotic pig model. Together these data suggest that a BKI-mediated therapeutic may be an effective treatment against cryptosporidiosis.

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