Open AccessReduced Susceptibility to Cefepime among Escherichia coli Clinical Isolates Producing Novel Variants of CMY-2 β-Lactamase
Author(s) -
Yohei Doi,
David L. Paterson,
Jennifer AdamsHaduch,
Hanna E. Sidjabat,
Alexandra O’Keefe,
Andrea Endimiani,
Robert A. Bonomo
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00133-09
Subject(s) - cefepime , escherichia coli , microbiology and biotechnology , biology , gene , genetics , antibiotics , antibiotic resistance , imipenem
Here we describe threeEscherichia coli clinical isolates with reduced susceptibility to cefepime. Sequencing of thebla CMY genes revealed two novel variants (CMY-33 and -44) with two- to four-amino-acid deletions in the H-10 helix. The deletions were responsible for 12- to 24-fold increases in the MICs of cefepime.
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