In Vitro Activities of the New Antitubercular Agents PA-824 and BTZ043 against Nocardia brasiliensis | Zendy

Lucio VeraCabrera | Zendy; Mayra Paola Campos-Rivera | Zendy; Norma Alejandra González-Martínez | Zendy; Jorge OcampoCandiani | Zendy; Stewart T. Cole | Zendy

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In Vitro Activities of the New Antitubercular Agents PA-824 and BTZ043 against Nocardia brasiliensis

Author(s) -

Lucio VeraCabrera,

Mayra Paola Campos-Rivera,

Norma Alejandra González-Martínez,

Jorge OcampoCandiani,

Stewart T. Cole

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00115-12

Subject(s) - nocardia brasiliensis , microbiology and biotechnology , in vitro , nocardia , in vivo , biology , chemistry , bacteria , nocardiosis , biochemistry , genetics

The in vitro activity of PA-824 and BTZ043 against 30 Nocardia brasiliensis isolates was tested. The MIC(50) and MIC(90) values for PA-824 were both >64 μg/ml. The same values for BTZ043 were 0.125 and 0.250 μg/ml. Given the MIC values for benzothiazinone (BTZ) compounds, we consider them good candidates to be tested in vivo against N. brasiliensis.

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