Open AccessDominance of bla CTX-M within an Australian Extended-Spectrum β-Lactamase Gene Pool
Author(s) -
Zhiyong Zong,
Sally R. Partridge,
L. Thomas,
Jonathan R. Iredell
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00107-08
Subject(s) - klebsiella pneumoniae , biology , plasmid , gene , dominance (genetics) , escherichia coli , ceftazidime , genetics , microbiology and biotechnology , enterobacteriaceae , beta lactamase , bacteria , pseudomonas aeruginosa
bla CTX-M genes, particularlybla CTX-M-15 , are the dominant extended-spectrum β-lactamase (ESBL) genes among clinical isolates ofEscherichia coli andKlebsiella pneumoniae in Sydney, Australia, where we also found one example ofbla CTX-M-62 , encoding a novel enzyme conferring ceftazidime resistance. ESBL genes were present in diverse community isolates and in a variety of associated conjugative plasmids.