Prevalence, Characteristics, and Molecular Epidemiology of Macrolide and Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae at Five Tertiary-Care Hospitals in Korea | Zendy

Jeong Hwan Shin | Zendy; Hee Jung Jung | Zendy; Hye Ran Kim | Zendy; Joseph Jeong | Zendy; Seok Hoon Jeong | Zendy; SunJoo Kim | Zendy; Eun Yup Lee | Zendy; Jeong Nyeo Lee | Zendy; Chulhun L. Chang | Zendy

Open Access

Prevalence, Characteristics, and Molecular Epidemiology of Macrolide and Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae at Five Tertiary-Care Hospitals in Korea

Author(s) -

Jeong Hwan Shin,

Hee Jung Jung,

Hye Ran Kim,

Joseph Jeong,

Seok Hoon Jeong,

SunJoo Kim,

Eun Yup Lee,

Jeong Nyeo Lee,

Chulhun L. Chang

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00107-07

Subject(s) - levofloxacin , streptococcus pneumoniae , microbiology and biotechnology , quinolone , erythromycin , streptococcus pyogenes , streptococcaceae , efflux , ofloxacin , antibacterial agent , biology , antibiotics , medicine , ciprofloxacin , bacteria , genetics , staphylococcus aureus

The genes erm(B), mef(A), and both erm(B) and mef(A) were identified in 42.6, 10.1, and 47.3%, respectively, of the erythromycin-resistant Streptococcus pneumoniae isolates. Of the strains, 3.8% were nonsusceptible to levofloxacin and had 1 to 6 amino acid changes in the quinolone resistance-determining region, including a new mutation, Asn94Ser, in the product of parC. Levofloxacin with reserpine was highly specific for efflux screening.

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