Enhancement of Human Immunodeficiency Virus Type 1 Replication Is Not Intrinsic to All Polyanion-Based Microbicides | Zendy

Secondo Sonza | Zendy; Adam Johnson | Zendy; David Tyssen | Zendy; Tim Spelman | Zendy; G.R. Lewis | Zendy; Jeremy Ra Paull | Zendy; Gilda Tachedjian | Zendy

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Enhancement of Human Immunodeficiency Virus Type 1 Replication Is Not Intrinsic to All Polyanion-Based Microbicides

Author(s) -

Secondo Sonza,

Adam Johnson,

David Tyssen,

Tim Spelman,

G.R. Lewis,

Jeremy Ra Paull,

Gilda Tachedjian

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00102-09

Subject(s) - virology , microbicides for sexually transmitted diseases , human immunodeficiency virus (hiv) , viral replication , lentivirus , replication (statistics) , virus , biology , viral disease , medicine , population , environmental health , health services

Polyanion-based microbicides have been developed to prevent the sexual transmission of human immunodeficiency virus (HIV). Recent data suggest that polyanions have the capacity to enhance HIV type 1 (HIV-1) replication at threshold antiviral concentrations. Evaluation of the microbicide candidates SPL7013 and PRO 2000 revealed no specific enhancement of two CCR5 HIV-1 strains in human peripheral blood mononuclear cells compared to enfuvirtide (Fuzeon). The enhancement effect is likely to be a function of the assay conditions and is not an intrinsic property of these polyanions.

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