Tn 6350 , a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa | Zendy

Helena Turano | Zendy; Fernando Gomes | Zendy; Gesiele Almeida Barros-Carvalho | Zendy; Ralf Lopes | Zendy; Louise Cerdeira | Zendy; L.E.S. Netto | Zendy; Ana Cristina Gales | Zendy; Nilton Lincopán | Zendy

Open Access

Tn 6350 , a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa

Author(s) -

Helena Turano,

Fernando Gomes,

Gesiele Almeida Barros-Carvalho,

Ralf Lopes,

Louise Cerdeira,

L.E.S. Netto,

Ana Cristina Gales,

Nilton Lincopán

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00100-17

Subject(s) - transposase , orfs , transposable element , pseudomonas aeruginosa , biology , open reading frame , plasmid , bacteriocin , gene , genetics , microbiology and biotechnology , transposition (logic) , mutant , peptide sequence , bacteria , linguistics , philosophy

A novel transposon belonging to the Tn 3 -like family was identified on the chromosome of a commensal strain of Pseudomonas aeruginosa sequence type 2343 (ET02). Tn 6350 is 7,367 bp long and harbors eight open reading frames (ORFs), an ATPase (IS 481 family), a transposase (DDE catalytic type), a Tn 3 resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with its immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing P. aeruginosa , including IMP-1, SPM-1, VIM-1, GES-5, and KPC-2 producers.

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