Environmental Isolates of Azole-Resistant Aspergillus fumigatus in Germany | Zendy

Oliver Bader | Zendy; Jana Tünnermann | Zendy; Anna Dudakova | Zendy; Marut Tangwattanachuleeporn | Zendy; Michael Weig | Zendy; Uwe Groß | Zendy

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Environmental Isolates of Azole-Resistant Aspergillus fumigatus in Germany

Author(s) -

Oliver Bader,

Jana Tünnermann,

Anna Dudakova,

Marut Tangwattanachuleeporn,

Michael Weig,

Uwe Groß

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00100-15

Subject(s) - aspergillus fumigatus , azole , biology , microbiology and biotechnology , aspergillus , genotype , drug resistance , allele , aspergillosis , fungi imperfecti , antifungal , genetics , gene , immunology

Azole antifungal drug resistance in Aspergillus fumigatus is an emerging problem in several parts of the world. Here we investigated the distribution of such strains in soils from Germany. At a general positivity rate of 12%, most prevalently, we found strains with the TR34/L98H and TR46/Y121F/T289A alleles, dispersed along a corridor across northern Germany. Comparison of the distributions of resistance alleles and genotypes between environment and clinical samples suggests the presence of local clinical clusters.

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