Open AccessParadoxical Effect of Echinocandins across Candida Species In Vitro: Evidence for Echinocandin-Specific and Candida Species-Related Differences
Author(s) -
Georgios Chamilos,
Russell E. Lewis,
Nathaniel D. Albert,
Dimitrios P. Kontoyiannis
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00095-07
Subject(s) - echinocandins , anidulafungin , echinocandin , micafungin , caspofungin , candida parapsilosis , microbiology and biotechnology , candida krusei , biology , candida glabrata , candida tropicalis , candida albicans , fungemia , antifungal , fluconazole
Paradoxical growth of someCandida isolates occurs at concentrations above the MIC for echinocandins. In 60Candida bloodstream isolates from cancer patients (20C. albicans isolates and 10 isolates each ofC. parapsilosis ,C. tropicalis ,C. krusei , andC. glabrata ), paradoxical growth was more frequent with caspofungin than micafungin or anidulafungin, was unrelated to MIC, and was strikingly absent inC. glabrata isolates.