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Clinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found (r(2) = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.

antimicrobial agents and chemotherapy

Increasing Incidence of Linezolid-Intermediate or -Resistant, Vancomycin-Resistant <i>Enterococcus faecium</i> Strains Parallels Increasing Linezolid Consumption

Increasing Incidence of Linezolid-Intermediate or -Resistant, Vancomycin-Resistant Enterococcus faecium Strains Parallels Increasing Linezolid Consumption