Increasing Incidence of Linezolid-Intermediate or -Resistant, Vancomycin-Resistant Enterococcus faecium Strains Parallels Increasing Linezolid Consumption | Zendy

Marc H. Scheetz | Zendy; Stephanie A. Knechtel | Zendy; Michael Malczynski | Zendy; Michael Postelnick | Zendy; Chao Qi | Zendy

Open Access

Increasing Incidence of Linezolid-Intermediate or -Resistant, Vancomycin-Resistant Enterococcus faecium Strains Parallels Increasing Linezolid Consumption

Author(s) -

Marc H. Scheetz,

Stephanie A. Knechtel,

Michael Malczynski,

Michael Postelnick,

Chao Qi

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00070-08

Subject(s) - linezolid , enterococcus faecium , vancomycin , enterococcus , microbiology and biotechnology , incidence (geometry) , antibiotics , antibacterial agent , medicine , biology , bacteria , staphylococcus aureus , genetics , physics , optics

Clinical enterococcal resistance to linezolid is defined by the presence of the G2576T mutation. We evaluated the incidence of genetically proven linezolid resistance among vancomycin-resistant Enterococcus faecium strains and linezolid consumption for a possible association. A relationship was found (r(2) = 0.73, P = 0.03) and predicts increasing resistance with current trends of linezolid use.

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