Oligochlorophens Are Potent Inhibitors of Bacillus anthracis | Zendy

Marie H. Foss | Zendy; Douglas B. Weibel | Zendy

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Oligochlorophens Are Potent Inhibitors of Bacillus anthracis

Author(s) -

Marie H. Foss,

Douglas B. Weibel

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00067-10

Subject(s) - bacillus anthracis , ftsz , antibiotics , microbiology and biotechnology , antimicrobial , pathogen , bacteria , cytoskeleton , biology , antibiotic resistance , bacterial protein , chemistry , biochemistry , genetics , cell

Bacterial cytoskeletal proteins are an emerging set of targets for antibiotic development. This paper describes oligochlorophen analogs based on the monomer 4-chloro-2,6-dimethylphenol as antimicrobial agents against Bacillus anthracis. The most potent analogs have a MIC of 160 to 320 nM against B. anthracis and may target the cytoskeletal protein FtsZ. B. anthracis develops resistance to the oligochlorophens at a rate of 4.34 x 10(-10) per generation, which is approximately 10-fold lower than that of commercial antibiotics used to treat this human pathogen.

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