Open AccessStability of Extemporaneously Prepared 0.5-Percent Caspofungin Eye Drops: a Potential Cost-Savings Exercise
Author(s) -
Chin Fen Neoh,
Jovan Jacob,
Lok Leung,
Jian Li,
Angela Stathopoulos,
Kay Stewart,
David C. M. Kong
Publication year - 2012
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00060-12
Subject(s) - caspofungin , limiting , high performance liquid chromatography , chromatography , medicine , anesthesia , chemistry , antifungal , dermatology , amphotericin b , mechanical engineering , engineering
While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis. The preparations remained stable for 28 days under refrigerated condition but not at 25.0 °C. Our study supports the cost-saving use of caspofungin eye drops in the clinical setting.
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