Abrogation of Triazole Resistance upon Deletion of CDR1 in a Clinical Isolate of Candida auris | Zendy

Jeffrey M. Rybak | Zendy; Laura A. Doorley | Zendy; Andrew T. Nishimoto | Zendy; Katherine S. Barker | Zendy; Glen E. Palmer | Zendy; P. David Rogers | Zendy

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Abrogation of Triazole Resistance upon Deletion of CDR1 in a Clinical Isolate of Candida auris

Author(s) -

Jeffrey M. Rybak,

Laura A. Doorley,

Andrew T. Nishimoto,

Katherine S. Barker,

Glen E. Palmer,

P. David Rogers

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00057-19

Subject(s) - candida auris , candida albicans , biology , triazole , fungal pathogen , microbiology and biotechnology , gene , multiple drug resistance , homology (biology) , tertiary care , genome , pathogen , drug resistance , genetics , antifungal , medicine , chemistry , organic chemistry

Candida auris has rapidly emerged as a health care-associated and multidrug-resistant pathogen of global concern. In this work, we examined the relative expression of the fourC. auris genes with the highest degree of homology toCandida albicans CDR1 andMDR1 among three triazole-resistant clinical isolates as compared to the triazole-susceptible genome reference clinical isolate.

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