Open AccessAntifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex
Author(s) -
Xue Kong,
Chao Tang,
Ashutosh Singh,
Sarah Ahmed,
Abdullah M. S. AlHatmi,
Anuradha Chowdhary,
Pietro Nenoff,
Yvonne Gräser,
Steven Hainsworth,
Ping Zhan,
Jacques F. Meis,
Paul E. Verweij,
Weida Liu,
G. Sybren de Hoog
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00056-21
Subject(s) - terbinafine , squalene monooxygenase , trichophyton , dermatophyte , biology , gene , voriconazole , squalene , microbiology and biotechnology , antifungal , genetics , itraconazole , biochemistry , biosynthesis
During the past decade, a prolonged and serious outbreak of dermatophytosis due to a terbinafine-resistant novel species in theTrichophyton mentagrophytes - T. interdigitale complex has been ongoing in India, and it has spread to several European countries. The objective of this study was to investigate the molecular background of the squalene epoxidase (SQLE ) gene in order to understand the risk of emergence and spread of multiresistance in dermatophytes.