Identification of Antimalarial Compounds That Require CLAG3 for Their Uptake by Plasmodium falciparum -Infected Erythrocytes | Zendy

Sofía Mira-Martínez | Zendy; Anastasia K. Pickford | Zendy; Núria RoviraGraells | Zendy; Pieter Guetens | Zendy; Elisabet Tintó-Font | Zendy; Alfred Cortés | Zendy; Anna RosanasUrgell | Zendy

Open Access

Identification of Antimalarial Compounds That Require CLAG3 for Their Uptake by Plasmodium falciparum -Infected Erythrocytes

Author(s) -

Sofía Mira-Martínez,

Anastasia K. Pickford,

Núria RoviraGraells,

Pieter Guetens,

Elisabet Tintó-Font,

Alfred Cortés,

Anna RosanasUrgell

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00052-19

Subject(s) - plasmodium falciparum , biology , malaria , plasmodium (life cycle) , erythrocyte membrane , artemisinin , virology , apicomplexa , red blood cell , parasite hosting , biochemistry , immunology , membrane , world wide web , computer science

During the intraerythrocytic asexual cycle malaria parasites acquire nutrients and other solutes through a broad selectivity channel localized at the membrane of the infected erythrocyte termed the plasmodial surface anion channel (PSAC). The protein product of thePlasmodium falciparum clonally variantclag3.1 andclag3.2 genes determines PSAC activity.

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