Antiviral and Anti-Inflammatory Effects of Rosmarinic Acid in an Experimental Murine Model of Japanese Encephalitis | Zendy

Vivek Swarup | Zendy; Joydeep Ghosh | Zendy; Soumya Ghosh | Zendy; Amit Saxena | Zendy; Anirban Basu | Zendy

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Antiviral and Anti-Inflammatory Effects of Rosmarinic Acid in an Experimental Murine Model of Japanese Encephalitis

Author(s) -

Vivek Swarup,

Joydeep Ghosh,

Soumya Ghosh,

Amit Saxena,

Anirban Basu

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00041-07

Subject(s) - rosmarinic acid , proinflammatory cytokine , viral encephalitis , japanese encephalitis , virus , encephalitis , virology , cytokine , medicine , immunology , biology , inflammation , biochemistry , antioxidant

Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 days postinfection.

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