Molecular Characterization of Ofloxacin-Resistant Mycobacterium tuberculosis Strains from Russia | Zendy

Igor Mokrousov | Zendy; Tatiana Otten | Zendy; Olga Manicheva | Zendy; Yulia Potapova | Zendy; Boris Vishnevsky | Zendy; Olga Narvskaya | Zendy; Nalin Rastogi | Zendy

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Molecular Characterization of Ofloxacin-Resistant Mycobacterium tuberculosis Strains from Russia

Author(s) -

Igor Mokrousov,

Tatiana Otten,

Olga Manicheva,

Yulia Potapova,

Boris Vishnevsky,

Olga Narvskaya,

Nalin Rastogi

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00036-08

Subject(s) - ofloxacin , mycobacterium tuberculosis , microbiology and biotechnology , tuberculosis , biology , virology , antibacterial agent , mycobacterium , antibiotics , bacteria , medicine , genetics , ciprofloxacin , pathology

In this work, we studied the variation in the gyrA and gyrB genes in ofloxacin- and multidrug-resistant Mycobacterium tuberculosis strains circulating in northwest Russia. Comparison with spoligotyping data suggested that similar to the spread of multidrug-resistant tuberculosis, the spread of fluoroquinolone-resistant tuberculosis in Russia may be due, at least partly, to the prevalence of the Beijing genotype in a local population of M. tuberculosis.

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