Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus | Zendy

H Fujii | Zendy; Shizuko Harada | Zendy; Tomoki Yoshikawa | Zendy; Souichi Yamada | Zendy; Natsumi Omura | Zendy; Miho Shibamura | Zendy; Takuya Inagaki | Zendy; Hirofumi Kato | Zendy; Shuetsu Fukushi | Zendy; Masayuki Saijo | Zendy

Open Access

Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus

Author(s) -

H Fujii,

Shizuko Harada,

Tomoki Yoshikawa,

Souichi Yamada,

Natsumi Omura,

Miho Shibamura,

Takuya Inagaki,

Hirofumi Kato,

Shuetsu Fukushi,

Masayuki Saijo

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00017-19

Subject(s) - thymidine kinase , virology , herpes simplex virus , virus , biology , recombinant dna , varicella zoster virus , herpesviridae , aciclovir , gene , alphaherpesvirinae , recombinant virus , mutation , viral disease , genetics

Acyclovir (ACV) resistance-associated mutations in two recombinant herpes simplex virus 1 (HSV-1) clones were compared. Recombinant HSV-1 lacking its thymidine kinase (TK) and expressing varicella-zoster virus (VZV) TK ectopically had no mutations in the VZV TK gene.

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