Open AccessCarriage of an ACME II Variant May Have Contributed to Methicillin-Resistant Staphylococcus aureus Sequence Type 239-Like Strain Replacement in Liverpool Hospital, Sydney, Australia
Author(s) -
Björn A. Espedido,
Jason A. Steen,
Thelma Barbagiannakos,
Joanne Mercer,
David L. Paterson,
Sean M. Grimmond,
Matthew A. Cooper,
Iain B. Gosbell,
S. J. van Hal,
Slade O. Jensen
Publication year - 2012
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00013-12
Subject(s) - carriage , staphylococcus aureus , microbiology and biotechnology , methicillin resistant staphylococcus aureus , biology , sccmec , whole genome sequencing , insertion sequence , strain (injury) , pulsed field gel electrophoresis , micrococcaceae , sequence (biology) , genetics , bacteria , genome , medicine , gene , genotype , pathology , transposable element , anatomy
Approximately 39% of methicillin-resistant Staphylococcus aureus (MRSA) sequence type 239 (ST239)-like bloodstream isolates from Liverpool Hospital (obtained between 1997 and 2008) carry an arginine catabolic mobile element (ACME). Whole-genome sequencing revealed that an ACME II variant is located between orfX and SCCmec III, and based on pulsed-field gel electrophoresis patterns and temporal relationships of all ST239-like isolates (n = 360), ACME carriage may have contributed to subpulsotype strain replacement.
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