Structural Variations of Staphylococcal Cassette Chromosome mec Type IVa in Staphylococcus aureus Clonal Complex 8 and Unrelated Lineages | Zendy

Peter Damborg | Zendy; Mette Damkjær Bartels | Zendy; Kit Boye | Zendy; Luca Guardabassi | Zendy; Henrik Westh | Zendy

Open Access

Structural Variations of Staphylococcal Cassette Chromosome mec Type IVa in Staphylococcus aureus Clonal Complex 8 and Unrelated Lineages

Author(s) -

Peter Damborg,

Mette Damkjær Bartels,

Kit Boye,

Luca Guardabassi,

Henrik Westh

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00012-11

Subject(s) - biology , mobile genetic elements , typing , staphylococcus aureus , genetics , multilocus sequence typing , microbiology and biotechnology , genome , gene , genotype , bacteria

PCR mapping of staphylococcal cassette chromosome mec type IVa and adjacent mobile elements in 94 methicillin-resistant Staphylococcus aureus (MRSA) strains identified two primary structures (A and B) that could be further classified into two (A1 and A2) and five (B1 to B5) variants, primarily based on structural differences in the orfX-J3 region. While spa type t008 (USA300) invariably contained the A variants, other spa types belonging to clonal complex 8 and unrelated lineages generally contained B variants. These findings have important implications for the typing and identification of MRSA strains containing B variants.

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