Open AccessPotent Activities of Luliconazole, Lanoconazole, and Eight Comparators against Molecularly Characterized Fusarium Species
Author(s) -
Mahdi Abastabar,
Abdullah M. S. AlHatmi,
Mohammad Vafaei Moghaddam,
Sybren de Hoog,
Iman Haghani,
Seyed Reza Âghili,
Tahereh Shokohi,
Mohammad Taghi Hedayati,
Roshanak Daie Ghazvini,
Reza Kachuei,
Ali RezaeiMatehkolaei,
Koichi Makimura,
Jacques F. Meis,
Hamid Badali
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00009-18
Subject(s) - fusarium , biology , microbiology and biotechnology , botany
A collection of clinical (n = 47) and environmental (n = 79)Fusarium isolates were tested against 10 antifungal drugs, including 2 novel imidazoles. Luliconazole and lanoconazole demonstrated very low geometric mean MIC values of 0.005 and 0.013 μg/ml, respectively, compared with 0.51 μg/ml for micafungin, 0.85 μg/ml for efinaconazole, 1.12 μg/ml for natamycin, 1.18 μg/ml for anidulafungin, 1.31 μg/ml for voriconazole, 1.35 μg/ml for caspofungin, 1.9 μg/ml for amphotericin B, and 4.08 μg/ml for itraconazole. Results show that these drugs are potential candidates for (topical) treatment of skin and nail infections due toFusarium species.
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