Tryptophan Inhibits Biofilm Formation by Pseudomonas aeruginosa | Zendy

Kenneth S. Brandenburg | Zendy; Karien J. Rodriguez | Zendy; Jonathan F. McAnulty | Zendy; Christopher J. Murphy | Zendy; Nicholas L. Abbott | Zendy; Michael J. Schurr | Zendy; Charles J. Czuprynski | Zendy

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Tryptophan Inhibits Biofilm Formation by Pseudomonas aeruginosa

Author(s) -

Kenneth S. Brandenburg,

Karien J. Rodriguez,

Jonathan F. McAnulty,

Christopher J. Murphy,

Nicholas L. Abbott,

Michael J. Schurr,

Charles J. Czuprynski

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00007-13

Subject(s) - biofilm , pseudomonas aeruginosa , tryptophan , microbiology and biotechnology , motility , chemistry , pseudomonadales , biology , bacteria , biochemistry , amino acid , genetics

Biofilm formation by Pseudomonas aeruginosa has been implicated in the pathology of chronic wounds. Both the d and l isoforms of tryptophan inhibited P. aeruginosa biofilm formation on tissue culture plates, with an equimolar ratio of d and l isoforms producing the greatest inhibitory effect. Addition of d-/l-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation by P. aeruginosa.

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