Open AccessAnalysis of Single-Nucleotide Polymorphisms in thecrt-oandmdr1Genes ofPlasmodium vivaxamong Chloroquine-Resistant Isolates from the Brazilian Amazon Region
Author(s) -
Pamela Orjuela-Sánchez,
Franklin Simões de Santana Filho,
Ariane MachadoLima,
Yonne F Chehuan,
Mônica Regina Farias Costa,
Maria das Graças Costa Alecrim,
Hernando A. del Portillo
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00004-09
Subject(s) - biology , plasmodium vivax , single nucleotide polymorphism , genetics , gene , plasmodium falciparum , virology , apicomplexa , snp , chloroquine , coding region , genotype , phenotype , malaria , immunology
Plasmodium vivax parasites with chloroquine resistance (CQR) are already circulating in the Brazilian Amazon. Complete single-nucleotide polymorphism (SNP) analyses of coding and noncoding sequences of the pvmdr1 and pvcrt-o genes revealed no associations with CQR, even if some mutations had not been randomly selected. In addition, striking differences in the topologies and numbers of SNPs in these transporter genes between P. vivax and P. falciparum reinforce the idea that mechanisms other than mutations may explain this virulent phenotype in P. vivax.
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