Open AccessReducing Mortality in Salmonella enterica Serovar Typhimurium-Infected Mice with a Tripeptidic Serum Fraction
Author(s) -
Todd Parker,
Kenneth O. Willeford,
Suzanne L. Parker,
Karyl K. Buddington
Publication year - 2002
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac;46.6.1971-1973.2002
Subject(s) - immunostimulant , salmonella enterica , salmonella , serotype , microbiology and biotechnology , medicine , biology , enterobacteriaceae , immunology , virology , bacteria , escherichia coli , immune system , genetics , biochemistry , gene
Salmonellosis-induced mortality in female Swiss Webster mice decreased significantly when tripeptidic immunostimulant (TPI) was administered prophylactically. Prophylactic benefits developed in a dose-dependent manner wherein 15 mg of TPI given 1 day before challenge reduced mortality by 70%.