Open AccessTargeting pancreatic islet PTP1B improves islet graft revascularization and transplant outcomes
Author(s) -
Hugo AlvesFigueiredo,
Ana Lucia C. Figueroa,
Ainhoa García,
Rebeca FernandezRuiz,
Christophe Broca,
Anne Wojtusciszyn,
Rita Malpique,
Rosa Gasa,
Ramón Gomis
Publication year - 2019
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aar6294
Subject(s) - islet , transplantation , medicine , endocrinology , revascularization , hypoxia (environmental) , pancreatic islets , cancer research , insulin , chemistry , organic chemistry , oxygen , myocardial infarction
Inhibition of tyrosine phosphatase PTP1B in mouse and human islets promotes islet revascularization and improves graft survival and function.
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