Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability | Zendy

Andrew J. King | Zendy; Matthew Siegel | Zendy; Ying He | Zendy; Baoming Nie | Zendy; Ji Wang | Zendy; Samantha Koo-McCoy | Zendy; Natali A. Minassian | Zendy; Qumber Jafri | Zendy; Pan Deng | Zendy; Jill Kohler | Zendy; Padmapriya Kumaraswamy | Zendy; Kenji Kozuka | Zendy; Jason G. Lewis | Zendy; Dean Dragoli | Zendy; David P. Rosenbaum | Zendy; Debbie O’Neill | Zendy; Allein Plain | Zendy; Peter J. Greasley | Zendy; AnnCathrine JönssonRylander | Zendy; Daniel Karlsson | Zendy; Margareta Behrendt | Zendy; Maria Strömstedt | Zendy; Tina RydénBergsten | Zendy; Thomas Knöpfel | Zendy; Eva Maria Pastor Arroyo | Zendy; Nati Hernando | Zendy; Joanne Marks | Zendy; Mark Donowitz | Zendy; Carsten A. Wagner | Zendy; R. Todd Alexander | Zendy; Jeremy S. Caldwell | Zendy

Open Access

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability

Author(s) -

Andrew J. King,

Matthew Siegel,

Ying He,

Baoming Nie,

Ji Wang,

Samantha Koo-McCoy,

Natali A. Minassian,

Qumber Jafri,

Pan Deng,

Jill Kohler,

Padmapriya Kumaraswamy,

Kenji Kozuka,

Jason G. Lewis,

Dean Dragoli,

David P. Rosenbaum,

Debbie O’Neill,

Allein Plain,

Peter J. Greasley,

AnnCathrine JönssonRylander,

Daniel Karlsson,

Margareta Behrendt,

Maria Strömstedt,

Tina RydénBergsten,

Thomas Knöpfel,

Eva Maria Pastor Arroyo,

Nati Hernando,

Joanne Marks,

Mark Donowitz,

Carsten A. Wagner,

R. Todd Alexander,

Jeremy S. Caldwell

Publication year - 2018

Publication title -

science translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.819

H-Index - 216

eISSN - 1946-6242

pISSN - 1946-6234

DOI - 10.1126/scitranslmed.aam6474

Subject(s) - paracellular transport , phosphate , sodium , chemistry , permeability (electromagnetism) , gastrointestinal tract , biochemistry , organic chemistry , membrane

Tenapanor inhibits sodium/hydrogen exchanger isoform 3 to reduce intestinal phosphate absorption via reduction of passive paracellular phosphate flux.

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