Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
Author(s) -
Richard D. Gordon,
Eduardo A. Albornoz,
Daniel C. Christie,
Monica R. Langley,
Vinod Kumar,
Susanna Mantovani,
Avril A. B. Robertson,
Mark S. Butler,
Dominic B. Rowe,
Luke O'neill,
Anumantha G. Kanthasamy,
Kate Schroder,
Matthew A. Cooper,
Trent M. Woodruff
Publication year - 2018
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aah4066
Subject(s) - inflammasome , substantia nigra , neuroinflammation , neurodegeneration , dopaminergic , microglia , pyrin domain , pyroptosis , parkinson's disease , neuroscience , microbiology and biotechnology , caspase 1 , alpha synuclein , chemistry , biology , medicine , pathology , immunology , inflammation , dopamine , disease
Oral treatment with a brain-penetrant NLRP3 inhibitor has protective effects in preclinical models of Parkinson’s disease.
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