Open AccessAntibiotics, birth mode, and diet shape microbiome maturation during early life
Author(s) -
Nicholas A. Bokulich,
Jennifer Chung,
Thomas Battaglia,
Nora Henderson,
Melanie Jay,
Huilin Li,
Ar D. Lieber,
Fen Wu,
Guillermo I. Perez-Perez,
Yu Chen,
William Schweizer,
Xuhui Zheng,
Mónica Contreras,
Maria Gloria Domínguez-Bello,
Martin J. Blaser
Publication year - 2016
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aad7121
Subject(s) - antibiotics , microbiome , formula feeding , medicine , physiology , biology , pediatrics , bioinformatics , microbiology and biotechnology , breast feeding
Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.
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