Open AccessA cocktail of humanized anti–pertussis toxin antibodies limits disease in murine and baboon models of whooping cough
Author(s) -
Annalee W. Nguyen,
Ellen K. Wagner,
Joshua R. Laber,
Laura L. Goodfield,
William E. Smallridge,
Eric T. Harvill,
James F. Papin,
Roman F. Wolf,
Eduardo A. Padlan,
Andy Bristol,
Michael Kaleko,
Jennifer A. Maynard
Publication year - 2015
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aad0966
Subject(s) - whooping cough , medicine , baboon , pertussis toxin , antibody , virology , immunology , toxin , pharmacology , specific antibody , biology , microbiology and biotechnology , vaccination , receptor , g protein
A humanized antibody cocktail alleviates the high white blood cell count associated with severe pertussis infection and increases bacterial clearance in murine and baboon models.
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