ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma | Zendy

Carl Koschmann | Zendy; AndaAlexandra Calinescu | Zendy; Felipe J. Núñez | Zendy; Alan Mackay | Zendy; Janet Fazal-Salom | Zendy; Danièl Thomas | Zendy; Flor Mendez | Zendy; Neha Kamran | Zendy; Marta Dzaman | Zendy; Lakshman Mulpuri | Zendy; Johnathon Krasinkiewicz | Zendy; Robert Doherty | Zendy; Rosemary Lemons | Zendy; Jacqueline A. BrosnanCashman | Zendy; Youping Li | Zendy; Soyeon Roh | Zendy; Lili Zhao | Zendy; Henry D. Appelman | Zendy; David O. Ferguson | Zendy; Vera Gorbunova | Zendy; Alan K. Meeker | Zendy; Chris Jones | Zendy; Pedro R. Löwenstein | Zendy; María G. Castro | Zendy

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ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

Author(s) -

Carl Koschmann,

AndaAlexandra Calinescu,

Felipe J. Núñez,

Alan Mackay,

Janet Fazal-Salom,

Danièl Thomas,

Flor Mendez,

Neha Kamran,

Marta Dzaman,

Lakshman Mulpuri,

Johnathon Krasinkiewicz,

Robert Doherty,

Rosemary Lemons,

Jacqueline A. BrosnanCashman,

Youping Li,

Soyeon Roh,

Lili Zhao,

Henry D. Appelman,

David O. Ferguson,

Vera Gorbunova,

Alan K. Meeker,

Chris Jones,

Pedro R. Löwenstein,

María G. Castro

Publication year - 2016

Publication title -

science translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.819

H-Index - 216

eISSN - 1946-6242

pISSN - 1946-6234

DOI - 10.1126/scitranslmed.aac8228

Subject(s) - atrx , non homologous end joining , glioma , dna repair , dna damage , dna , cancer research , biology , microbiology and biotechnology , medicine , genetics , mutation , gene

The loss of ATRX impairs DNA repair, promoting glioma growth but enhancing sensitivity to DNA-damaging therapies.

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