Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation | Zendy

Cameron McDonald-Hyman | Zendy; Laurence A. Turka | Zendy; Bruce R. Blazar | Zendy

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Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

Author(s) -

Cameron McDonald-Hyman,

Laurence A. Turka,

Bruce R. Blazar

Publication year - 2015

Publication title -

science translational medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.819

H-Index - 216

eISSN - 1946-6242

pISSN - 1946-6234

DOI - 10.1126/scitranslmed.aaa6853

Subject(s) - solid organ , hematopoietic stem cell transplantation , transplantation , immunotherapy , medicine , graft versus host disease , stem cell , organ transplantation , immunology , hematopoietic stem cell , disease , haematopoiesis , intensive care medicine , immune system , biology , pathology , genetics

Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulating therapies in preclinical development and in clinical trials that may allow these obstacles to be overcome.

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