Open AccessSpreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models
Author(s) -
Isamu Aiba,
Jeffrey L. Noebels
Publication year - 2015
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.aaa4050
Subject(s) - depolarization , brainstem , cardiorespiratory arrest , epilepsy , cardiorespiratory fitness , sudden death , neuroscience , medicine , anesthesia , biology
Ion channel mutations that cause epilepsy also predispose the immature brainstem to generate a depolarizing, tsunami-like wave that leads to autonomic collapse and death.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom