Open AccessSingle-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells
Author(s) -
Christos Karathanasis,
Juliane Medler,
Franziska Fricke,
Sonja Smith,
Sebastian Malkusch,
Darius Widera,
Simone Fulda,
Harald Wajant,
Sjoerd J. L. van Wijk,
Ivan Đikić,
Mike Heilemann
Publication year - 2020
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aax5647
Subject(s) - membrane , microbiology and biotechnology , tumor necrosis factor alpha , molecule , chemistry , biophysics , biology , immunology , biochemistry , organic chemistry
Ligand binding triggers the oligomerization of TNFR1 monomers and dimers into trimers and higher-order oligomers.
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