Open AccessNoncompetitive inhibitors of TNFR1 probe conformational activation states
Author(s) -
Chih Hung Lo,
Tory Schaaf,
Benjamin D. Grant,
Colin Kin-Wye Lim,
Prachi Bawaskar,
Courtney C. Aldrich,
David D. Thomas,
Jonathan N. Sachs
Publication year - 2019
Publication title -
science signaling
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aav5637
Subject(s) - chemistry , small molecule , pharmacology , biophysics , stereochemistry , medicine , biochemistry , biology
A small molecule that noncompetitively inhibits TNFR1 could be optimized to treat inflammatory diseases.
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