mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β 1 –induced collagen biosynthesis | Zendy

Brintha Selvarajah | Zendy; Ilan Azuelos | Zendy; Manuela Platé | Zendy; Delphine Guillotin | Zendy; Ellen Forty | Zendy; Greg Contento | Zendy; Hannah V. Woodcock | Zendy; Matthew Redding | Zendy; Adam Taylor | Zendy; Gino Brunori | Zendy; Pascal F. Durrenberger | Zendy; Riccardo Ronzoni | Zendy; Andy Blanchard | Zendy; Paul F. Mercer | Zendy; Dimitrios Anastasiou | Zendy; Rachel C. Chambers | Zendy

Open Access

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β ₁ –induced collagen biosynthesis

Author(s) -

Brintha Selvarajah,

Ilan Azuelos,

Manuela Platé,

Delphine Guillotin,

Ellen Forty,

Greg Contento,

Hannah V. Woodcock,

Matthew Redding,

Adam Taylor,

Gino Brunori,

Pascal F. Durrenberger,

Riccardo Ronzoni,

Andy Blanchard,

Paul F. Mercer,

Dimitrios Anastasiou,

Rachel C. Chambers

Publication year - 2019

Publication title -

science signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.659

H-Index - 154

eISSN - 1937-9145

pISSN - 1945-0877

DOI - 10.1126/scisignal.aav3048

Subject(s) - serine , biosynthesis , glycine , mtorc1 , microbiology and biotechnology , atf4 , chemistry , biochemistry , transforming growth factor , biology , amino acid , signal transduction , gene , phosphorylation , downregulation and upregulation , pi3k/akt/mtor pathway

Through mTORC1 signaling, TGF-β1 stimulates glycine synthesis from glucose to support collagen production in lung fibroblasts.

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