Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH
Author(s) -
Dalee Zhou,
Koji Ota,
Charlée Nardin,
Michelle Feldman,
Adam J. Widman,
Olivia Wind,
Amanda Simon,
Michael Reilly,
Lonny R. Levin,
Jochen Buck,
Kazumasa Wakamatsu,
Shosuke Ito,
Jonathan H. Zippin
Publication year - 2018
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aau7987
Subject(s) - melanosome , adenylyl cyclase , mechanism (biology) , biology , polyploid , microbiology and biotechnology , adcy9 , chemistry , cancer research , melanin , biochemistry , signal transduction , gene , genome , philosophy , epistemology
Inhibitors of soluble adenylyl cyclase increase pigmentation and may reduce the risk of skin cancer.
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