Open AccessSubstrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1
Author(s) -
Sam A. Jamieson,
Zheng Ruan,
Abigail E. Burgess,
Jack R. Curry,
Hamish D. McMillan,
Jodi L. Brewster,
Anita K. Dunbier,
Alison D. Axtman,
Natarajan Kannan,
Peter D. Mace
Publication year - 2018
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aau0597
Subject(s) - allosteric regulation , substrate specificity , substrate (aquarium) , microbiology and biotechnology , chemistry , biology , biochemistry , enzyme , ecology
Allosteric regulation of the pseudokinase TRIB1 reveals the therapeutic potential of kinase inhibitors.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom