Open AccessManganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Author(s) -
Souvarish Sarkar,
Dharmin Rokad,
Emir Malovic,
Jie Luo,
Dilshan S. Harischandra,
Huajun Jin,
Vellareddy Anantharam,
Xuemei Huang,
Mechelle M. Lewis,
Arthi Kanthasamy,
Anumantha G. Kanthasamy
Publication year - 2019
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aat9900
Subject(s) - inflammasome , microvesicles , signal transducing adaptor protein , microbiology and biotechnology , chemistry , signal transduction , manganese , inflammation , biology , immunology , microrna , biochemistry , organic chemistry , gene
Exosomes containing the adaptor ASC spread NLRP3 inflammasome activation between cells after manganese exposure.
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