Open AccessPhosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function
Author(s) -
Alexander I. Salter,
Richard G. Ivey,
Jacob J. Kennedy,
Valentin Voillet,
Anusha Rajan,
Eva J. Alderman,
Uliana J. Voytovich,
Chenwei Lin,
Daniel Sommermeyer,
Lingfeng Liu,
Jeffrey R. Whiteaker,
Raphaël Gottardo,
Amanda G. Paulovich,
Stanley R. Riddell
Publication year - 2018
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aat6753
Subject(s) - cd28 , intracellular , microbiology and biotechnology , chimeric antigen receptor , signal transduction , receptor , antigen , function (biology) , biology , affect (linguistics) , t cell , chemistry , immune system , immunology , biochemistry , psychology , communication
How potently CAR T cells with CD28 or 4-1BB costimulatory domains stimulate intracellular signaling correlates with treatment efficacy.
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