Open AccessCancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
Author(s) -
Katharine A. White,
Diego Garrido Ruiz,
Zachary A. Szpiech,
Nicolas Strauli,
Ryan D. Hernandez,
Matthew P. Jacobson,
Diane L. Barber
Publication year - 2017
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aam9931
Subject(s) - mutant , histidine , arginine , cancer , mutation , microbiology and biotechnology , biochemistry , biology , chemistry , cancer research , genetics , amino acid , gene
High intracellular pH in cancer cells enables the oncogenic effects of Arg-to-His mutations in proteins.
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