Open AccessAcetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
Author(s) -
Naoe Taira Nihira,
Kohei Ogura,
Kouhei Shimizu,
Brian J. North,
Jinfang Zhang,
Daming Gao,
Hiroyuki Inuzuka,
Wenyi Wei
Publication year - 2017
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1945-0877
pISSN - 1937-9145
DOI - 10.1126/scisignal.aai8026
Subject(s) - ubiquitin ligase , microbiology and biotechnology , mdm2 , acetylation , function (biology) , ubiquitin , biology , chemistry , cancer research , biochemistry , gene
Acetylation of MDM2 promotes its oncogenic function by blocking its self-ubiquitination while enhancing its ubiquitination of the tumor suppressor p53.
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