Open AccessConservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway
Author(s) -
Tujin Shi,
Mario Niepel,
Jason McDermott,
Yuqian Gao,
Carrie Nicora,
William Chrisler,
Lye Meng Markillie,
Vladislav Petyuk,
Richard Smith,
Karin Rodland,
Peter K. Sorger,
Weijun Qian,
H Wiley
Publication year - 2016
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aaf0891
Subject(s) - biology , mapk/erk pathway , microbiology and biotechnology , signal transduction , cell , proteomics , cell growth , genetics , gene
Abundance of most EGFR-MAPK pathway proteins is conserved across cell types, revealing adaptors as rate-limiting nodes.
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