Open AccessTargeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL -rearranged AML
Author(s) -
Isabel Morgado-Palacin,
Amanda Day,
Matilde Murga,
Vanesa Lafarga,
Marta Elena Antón,
Anthony Tubbs,
Hua-Tang Chen,
Aysegul V. Ergen,
Rhonda Anderson,
Avinash Bhandoola,
Kurt G. Pike,
Bernard Barlaam,
Elaine Cadogan,
Xi Wang,
Andrew J. Pierce,
Chad Hubbard,
Scott A. Armstrong,
André Nussenzweig,
Óscar Fernández-Capetillo
Publication year - 2016
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aad8243
Subject(s) - kinase , cancer research , leukemia , microbiology and biotechnology , biology , chemistry , medicine , genetics
Chemotherapy-resistant acute myeloid leukemia may respond to inhibition of ATR or ATM.
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