Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake | Zendy

Jonathan W. Haskins | Zendy; Shan Zhang | Zendy; Robert E. Means | Zendy; Joanne K. Kelleher | Zendy; Gary W. Cline | Zendy; Alberto CanfránDuque | Zendy; Yajaira Suárez | Zendy; David F. Stern | Zendy

Open Access

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

Author(s) -

Jonathan W. Haskins,

Shan Zhang,

Robert E. Means,

Joanne K. Kelleher,

Gary W. Cline,

Alberto CanfránDuque,

Yajaira Suárez,

David F. Stern

Publication year - 2015

Publication title -

science signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.659

H-Index - 154

eISSN - 1937-9145

pISSN - 1945-0877

DOI - 10.1126/scisignal.aac5124

Subject(s) - erbb4 , neuregulin 1 , neuregulin , sterol regulatory element binding protein , epidermal growth factor , cholesterol , pcsk9 , epidermal growth factor receptor , oxysterol , chemistry , receptor , erbb , microbiology and biotechnology , lipoprotein , medicine , endocrinology , ldl receptor , biology , cancer research , biochemistry , sterol , receptor tyrosine kinase

The epidermal growth factor receptor family member ERBB4 stimulates cholesterol biosynthesis in breast epithelial cells.

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