Open AccessONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
Author(s) -
C. Leah B. Kline,
A. Pieter J. van den Heuvel,
Joshua E. Allen,
Varun V. Prabhu,
David T. Dicker,
Wafik S. ElDeiry
Publication year - 2016
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aac4374
Subject(s) - integrated stress response , kinase , microbiology and biotechnology , fight or flight response , atf4 , phosphorylation , cancer research , chemistry , biology , unfolded protein response , biochemistry , translation (biology) , messenger rna , gene , endoplasmic reticulum
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