Open AccessBinding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
Author(s) -
Shanmugam Panneer Selvam,
Ryan M. De Palma,
Joshua J. Oaks,
Natalia Oleinik,
Yuri K. Peterson,
Robert V. Stahelin,
Emmanuel Skordalakes,
Suriyan Ponnusamy,
Elizabeth GarrettMayer,
Charles D. Smith,
Besim Öğretmen
Publication year - 2015
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aaa4998
Subject(s) - telomerase , sphingolipid , phosphorylation , sphingosine , sphingosine 1 phosphate , microbiology and biotechnology , chemistry , biochemistry , biology , receptor , gene
Sphingosine 1-phosphate binds and stabilizes telomerase, a process that could be targeted to promote senescence and reduce cancer growth.
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