Open AccessSUMO deconjugation is required for arsenic-triggered ubiquitylation of PML
Author(s) -
Domenico Fasci,
Veronica G. Anania,
Jennie R. Lill,
Guy S. Salvesen
Publication year - 2015
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aaa3929
Subject(s) - ubiquitin , arsenic , chemistry , microbiology and biotechnology , biology , biochemistry , gene , organic chemistry
A chemotherapeutic triggers the degradation of an oncoprotein by inducing a switch from SUMO2 to SUMO1 at a specific lysine residue.
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