Open AccessIRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions
Author(s) -
Kohsuke Kanekura,
Xiucui Ma,
John T. Murphy,
Lihua Julie Zhu,
Abhinav Diwan,
Fumihiko Urano
Publication year - 2015
Publication title -
science signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.659
H-Index - 154
eISSN - 1937-9145
pISSN - 1945-0877
DOI - 10.1126/scisignal.aaa0341
Subject(s) - endoplasmic reticulum , microbiology and biotechnology , programmed cell death , cell , apoptosis , kinase , chemistry , biology , biochemistry
The kinase activity of IRE1 prevents cell death triggered by permeabilization of the ER by Bax and Bak.
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